A PATIENT WITH ASOPHILIC-EOSINOPHILIC-MYELOPROLIFERATIVE-DISORDER SHOWING MONOSOMY-7 AND HYPERHISTAMINEMIA

We encountered a male patient with marked basophilia and eosinophilia complicated by anemia, thrombocytopenia, myelofibrosis, and hyperhista minemia. Since morphological abnormalities were unclear and since chro mosome analysis showed 45,XY,-7, a diagnosis of basophilic-eosinophili c myeloproliferative disorder was made. After administration of predni solone and cytarabine ocfosfate, basophil and eosinophil levels decrea sed, but blasts transiently appeared in the peripheral blood. Chromoso me analysis performed at the time of appearance of blasts showed a clo ne with 45,XY,-7,del(16)(q22). Subsequently, pancytopenia developed, a fter which white blood cell count and its classification were normal, as were chromosome findings. In this patient, monosomy 7 seemed to hav e induced myeloproliferative disorder with basophilia and eosinophilia , and del(16)(q22) may have enhanced the eosinophilia.