Epidemiological risk factors of coronary heart disease are not causal in atherosclerosis

Authors
Citation
We. Stehbens, Epidemiological risk factors of coronary heart disease are not causal in atherosclerosis, CLIN EXP HY, 22(4), 2000, pp. 445-453
Citations number
42
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
CLINICAL AND EXPERIMENTAL HYPERTENSION
ISSN journal
10641963 → ACNP
Volume
22
Issue
4
Year of publication
2000
Pages
445 - 453
Database
ISI
SICI code
1064-1963(200005)22:4<445:ERFOCH>2.0.ZU;2-E
Abstract
Logic dictates that for scientific progress in atherogenesis "cause" must b e the sole prequisite without which the disease cannot occur. Nor can it be assumed that statistical associations (risk factors) with coronary heart d isease (CHD) are causal for atherosclerosis and extrapolations from correla tions with CHD incidence to atherosclerosis are invalid. Any factor conside red to play a role in atherogenesis requires pathological and experimental evidence consistent with the logic of Koch's specificity of cause and effec t. Current epidemiological misuse and manipulation of cause and risk factor s are contrary to the basic precepts of scientific logic and the fundamenta l need for precision in word usage. The term "risk factor", because of the current deeply entrenched false concept of causality has retarded medical p rogress and should be abandoned. Its adherents, guilty of a disservice to t he tenets of their discipline, have also sullied the scientific integrity o f medicine as a whole.