T. Origuchi et al., IL-1-mediated expression of membrane type matrix-metalloproteinase in rheumatoid osteoblasts, CLIN EXP RH, 18(3), 2000, pp. 333-339
Objective
To determine whether the activation of metalloproteinases can be achieved b
y the interaction of the inflammatory cytokine, IL-IP, with rheumatoid oste
oblasts.
Results
MMP-2 is not secreted by rheumatoid osteoblasts as a proenzyme; however; IL
-IP stimulation induced the secretion of MMP-2 as an active form from rheum
atoid osteoblasts. This MMP-2 activating activity was detected significantl
y in IL-IP-stimulated rheumatoid osteoblasts. In support of this result, IL
-I beta stimulation induced the expression of membrane type matrix-metallop
roteinase (MT-MMP) a newly-identified MMP-2 specific activator in rheumatoi
d osteoblasts.
Conclusion
These results suggest that IL-IP induces MMP-2 activation in part by up-reg
ulating MT-MMP expression and represents a new mechanism for. cytokine-medi
ated articular destruction in RA.