T. Matsumoto et al., IMMUNOHISTOCHEMICAL ANALYSIS OF GLUTATHIONE-S-TRANSFERASE-PI EXPRESSION IN OVARIAN-TUMORS, European journal of obstetrics, gynecology, and reproductive biology, 73(2), 1997, pp. 171-176
Objective: To explore the association between Glutathione S-transferas
e (GST) -pi expression and clinicopathologic features in ovarian tumor
s. Study Design: Immunohistochemical study was made to investigate GST
-pi expression in diverse ovarian tumors. Results: All 75 ovarian tumo
rs expressed GST-pi. There was no significant association between GST-
pi immunopositivity and clinicopathological features. In serous cystad
enocarcinoma, however, patients with weak GST-pi expression survived l
onger than those with moderate or strong GST-pi expression. Three of t
he 8 tumors that had expressed weak GST-pi initially increased GST-pi
expression after chemotherapy. Conclusion: GST-pi expression is common
in ovarian tumors and malignant tumors expressed more GST-pi than ben
ign tumors. GST-pi might play a major role in the development of drug
resistance in certain ovarian tumors and could be a useful marker of n
atural resistance and their future outcome. (C) 1997 Elsevier Science
Ireland Ltd.