A facile synthesis of carboxamides by dehydration condensation between free carboxylic acids and amines using O,O '-di(2-pyridyl) thiocarbonate as a coupling reagent

Authors
Shiina, I Saitoh, K Nakano, M Suenaga, Y Mukaiyama, T
Citation
I. Shiina et al., A facile synthesis of carboxamides by dehydration condensation between free carboxylic acids and amines using O,O '-di(2-pyridyl) thiocarbonate as a coupling reagent, COLL CZECH, 65(4), 2000, pp. 621-630
Citations number
20
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
65
Issue
4
Year of publication
2000
Pages
621 - 630
Database
ISI
SICI code
0010-0765(200004)65:4<621:AFSOCB>2.0.ZU;2-2
Abstract
Carboxamides are prepared in high yields by dehydration condensation betwee n nearly equimolar amounts of free carboxylic acids and amines both of whic h involve secondary or tertiary alkyl substituted ones with O,O'-di(2-pyrid yl) thiocarbonate, a coupling reagent, in the presence of a catalytic amoun t of 4-(dimethylamino)pyridine.