Based on the quark propagator in the instanton dilute liquid approximation,
we have determined the nonlocal four-quark condensate at the mean-field le
vel in the framework of global color symmetry model. By making use of this
formula, the vacuum susceptibility (pion susceptibility) was calculated in
this paper. The theoretical analysis and numerical calculation show that ev
en at the mean-field level the naive vacuum saturation approximation is not
a good approximation when we consider nonlocal four-quark condensate.