In vitro evaluation of newly synthesised [1,2,4]triazolo[1,5a]pyrimidine derivatives against Trypanosoma cruzi, Leishmania donovani and Phytomonas staheli

The antiprotozoal activity of newly synthesised compounds, all [1,2,4]triaz olo [1,5a]pyrimidine derivatives, was tested against the protozoan parasite s Trypanosonza cruzi, Leishmania donovani and Phytomonas staheli. Six of th ese compounds significantly inhibited in vitro cell growth of the epimastig ote forms of T. cruzi, and the promastigote forms of L. donovani and P. sta heli. Some of the compounds reached complete growth inhibition at 1 mu g/ml for 48 h of parasite/drug interaction. None of the compounds tested showed significant toxicity against cells of Aedes albopictus, mouse macrophages J-774A.1 and Lycopersicum esculentum at dosages five times greater than use d against parasites. (C) 2000 Elsevier Science Inc. All rights reserved.