The first organometallic antioestrogens and their antiproliferative effects

Authors
Jaouen, C Top, S Vessieres, A Leclercq, G Quivy, J Jin, L Croisy, J
Citation
C. Jaouen et al., The first organometallic antioestrogens and their antiproliferative effects, CR AC S IIC, 3(2), 2000, pp. 89-93
Citations number
26
Categorie Soggetti
Chemistry
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE
ISSN journal
13871609 → ACNP
Volume
3
Issue
2
Year of publication
2000
Pages
89 - 93
Database
ISI
SICI code
1387-1609(200002)3:2<89:TFOAAT>2.0.ZU;2-J
Abstract
Modification of the tamoxifen skeleton by a ferrocenyl unit, combined with lengthening of the basic -O(CH2)(n)N(CH3)(2) chain from n = 2 to n = 3, gen erates a new type of antioestrogen with unique properties. This molecule, 5 , easily accessible via a McMurry coupling reaction, is indeed effective ag ainst the proliferation of breast cancer cells via both the alpha oestradio l receptor and its newly discovered beta form. (C) 2000 Academie des scienc es / Editions scientifiques et medicales Elsevier SAS.