Increased circulating soluble intercellular adhesion molecule-1 in acute myocardial infarction: A possible predictor of reperfusion ventricular arrhythmias
T. Murohara et al., Increased circulating soluble intercellular adhesion molecule-1 in acute myocardial infarction: A possible predictor of reperfusion ventricular arrhythmias, CRIT CARE M, 28(6), 2000, pp. 1861-1864
Objectives: Myocardial ischemia/reperfusion induces ventricular reperfusion
arrhythmias (RAs). Significant parts of RAs are considered tb be evoked by
oxygen free radicals. Inasmuch as activated leukocytes release oxygen free
radicals, and as the intercellular adhesion molecule-1 (ICAM-1) plays a ma
jor role in leukocyte infiltration, we examined whether there may be a rela
tionship between plasma levers of soluble ICAM-1 (sICAM-1) and frequency of
RAs in patients with acute myocardial infarction (AN1).
Design: Prospective study comparing the two AMI patient groups with or with
out RAs.
Setting: Coronary care unit and cardiac catheterization laboratories in a g
eneral hospital.
Patients: Twenty-three AMI patients (eight women and 15 men, aged 32 to 79
yrs). Interventions: All patients received percutaneous balloon angioplasty
with or without previous intracoronary thrombolysis. Significant RAs were
defined as at least one of nonsustained ventricular tachycardia, multifocal
premature Ventricular contraction, and frequent premature ventricular cont
raction occurring
Measurements and Main Results: Plasma sICAM-1 levels were measured using an
enzyme-linked immunosorbent assay. The plasma sICAM-1 levels at admission
were significantly greater in RA(+) (243 +/- 60 ng/mL) than RA(-) group (19
2 +/- 44 ng/mL) (p < .05). We followed plasma sICAM-1 levels up to 3 wks, a
nd found that SICAM-1 levels were consistently higher in the RA(+) than the
RA(-) group. Simple regression analysis showed no significant relationship
between plasma sICAM-1 levels and age, systolic and diastolic blood pressu
res, or serum creatine kinase activity. The two AMI groups showed no differ
ences in age, gender, events of major coronary risk factors, preinfarction
angina, and medication.
Conclusions: The increase in the plasma levels of sICAM-1 was observed in p
atients manifesting ventricular RAs. This increase in sICAM-1 levels was ob
served as early as at admission. The increased plasma sICAM-1 levels may be
a useful biochemical marker for predicting myocardial reperfusion injury s
uch as RAs in AMI.