Bowen's disease of the glans penis (erythroplasia of Queyrat) in plasma cell balanitis

We report a case of a persistent penile plaque on the glans penis of allege dly more than 20 years' duration, which was refractory to circumcision and local treatment. Over the years, the patient repeatedly presented with a ci rcumscribed inflammatory lesion of the glans penis, diagnosed as Zoon's bal anitis on the basis of clinical aspects and two biopsies. Because of unresp onsiveness of the lesion to circumcision and focal steroid infiltration, re peated biopsies were performed in an attempt to rule out malignancy. Two fu rther biopsies were carried out. One again showed the features of a plasmac ellular inflammation, while the other finally revealed the histopathologic features of erythroplasia of Queyrat (carcinoma in situ or Bowen's disease of the glans penis). We assume that either the former biopsy specimens were taken from a plasma cell-rich reactive infiltrate around the neoplastic le sion, or that carcinoma in situ may have arisen due to the chronic inflamma tion of Zoon's balanitis plasmacellularis. Radiotherapy was performed with good clinical response and subsequent histopathologic proof of complete rem ission of the lesion.