Fusarium fingernail infection responsive to fluconazole intermittent therapy

A case of fingernail infection by Fusarium is presented. This nondermatophy tic mold is an infrequent cause of onychomycosis, more typically involving the great toenail. Characteristic histologic features including the presenc e of hyphae and chlamydoconia are helpful in rapid diagnosis and selection of appropriate antifungal therapy. Although Fusarium has shown resistance t o most antifungal medications in vitro, intermittent therapy with fluconazo le led to improvement in this patient.