Studies concerning the application of membrane distillation (MD) for the co
ncentration of spent solution from heparin production have been reported. T
he experiments were performed with polypropylene capillary membranes. These
membranes had pore sizes with a nominal and maximum diameter of 0.2 mu m a
nd 0.6 mu m, respectively, and 73% porosity. A rapid flux decline was obser
ved during the MD process of wastewater concentration as a consequence of b
oth fouling and scaling phenomena. Boiling of wastewater followed by filtra
tion permitted the separation of the foulants in the form of a deposit. Suc
h pretreated feed was concentrated by the MD process without a flux decline
. This process resulted in the production of pure water with electrical con
ductivity in the range of 5-10 mu S/cm and brine. The presence of Pseudomon
as and Streptococcus faecalis bacteria and Penicillium and Aspergillus fung
i was detected in the concentrated wastewater. The polypropylene membranes
used did not reject Streptococcus faecalis bacteria; hence, they were detec
ted in distillate.