Objective. To re-evaluate after 5 years the results of a randomised trial o
f cholecystectomy and lithotripsy for the treatment of symptomatic gallston
es.
Design: Late follow-up of a randomised controlled trial.
Setting: Teaching hospital, UK.
Subjects: 144 of the 179 patients originally randomised.
Interventions: Either elective open cholecystectomy under general anaesthes
ia or a maximum of 4 sessions of lithotripsy (up to 3000 shocks/session) on
consecutive days with no anaesthesia or analgesia.
Results: Of the original 87 patients randomised to be treated by lithotrips
y, 39 (45%) subsequently underwent cholecystectomy, most of them within 32
months of treatment ("crossover" group). Patients in both main groups had a
pronounced reduction in the number of episodes of pain at 5 years and sign
ificant reductions in the mean severity scores both on VAS and the McGill r
ating. Those in the crossover group had the worst scores. Gastrointestinal
symptoms improved in the two main groups, but again the crossover group did
least well. Quality of lift: improved significantly over baseline in the t
wo main groups, but was much poorer in the crossover group.
Conclusions: patients who had primary cholecystectomy were more likely to b
e free of pain than those treated by lithotripsy. Lithotripsy Save good sym
ptomatic results in 55% of patients, and this was not dependent on clearanc
e of stones. Patients who had a cholecystectomy after lithotripsy had the w
orst symptomatic results. It is difficult to identify patients who will not
benefit from lithotripsy, but the presence of many coexisting symptoms may
be an important predictor.