A. Taylor et al., MULTICENTER TRIAL VALIDATION OF A CAMERA-BASED METHOD TO MEASURE TC-99M MERCAPTOACETYLTRIGLYCINE, OR TC-99M MAG(3), CLEARANCE, Radiology, 204(1), 1997, pp. 47-54
PURPOSE: To evaluate an improved camera-based method for calculating t
he clearance of technetium-99m mercaptoacetyltriglycine (MAG(3)) in a
multicenter trial, MATERIALS AND METHODS: Tc99m MAG(3) scintigraphy wa
s performed in 49 patients at three sites in the United States and Can
ada. The percentage of the injected dose of Tc-99m MAG(3) in the kidne
y at 1-2, 1.0-2.5, and 2-3 minutes after injection was correlated with
the plasma-based Tc-99m MAG(3) clearances. The data were combined wit
h the results obtained in 20 additional patients in a previously publi
shed pilot study. RESULTS: Regression models correlating the plasma-ba
sed Tc-99m MAG(3) clearance with the percentage uptake in the kidney f
or each time interval were developed; there was no statistically signi
ficant difference among sites in the regression equations. Correction
for body surface area statistically significantly (P < .005) improved
the correlation coefficient for each time interval. For the 1.0-2.5-mi
nute interval, the body surface area-corrected correlation coefficient
for the four combined sites was .87, and it improved to .93 when one
outlier was omitted from the analysis. Similar results were obtained w
ith the other time intervals. Independent processing by two observers
showed no clinically important differences in the percentage dose in t
he kidney or in relative function. CONCLUSION: An improved camera-base
d method to calculate the clearance of Tc-99m MAG(3) was validated in
a multicenter trial.