Liver morphology and histochemistry in rats resulting from ingestion of sodium selenite and sodium fluoride

A morphological and histochemical assessment was made of the effect of sodi um selenite and sodium fluoride on oxidative and lysosomal enzyme activity in the liver of male rats. The compounds were administered separately and t ogether for a period of three months. Oxidative enzyme activity of alpha-gl ycerophosphate dehydrogenase (alpha-GIDH) and succinate dehydrogenase (SDH) increased with sodium selenite and decreased with sodium fluoride and with both compounds together. Sodium selenite in a dose of 10 mu g/kg body weig ht and sodium fluoride in a dose of 20 mg/kg body weight caused an increase in the activity of acid phosphatase (AcP), while the combined dose caused a decrease in the activity of this enzyme.