Artocarpol A, a novel constituent with potent anti-inflammatory effect, isolated from Artocarpus rigida

A novel phenolic compound, artocarpol A (1), was isolated from the root bar k of Artocarpus rigida and its structure determined by spectroscopic method s and by comparison with its diacetate derivative. Compound 1 strongly inhi bited superoxide formation in phorbol 12-myristate 13-acetate (PMA) stimula ted rat neutrophils in a concentration-dependent manner with an IC, value o f 13.7 +/- 0.7 mu M. Compound 1 also showed a significant inhibitory effect on tumor necrosis factor-alpha (TNF-alpha) formation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.