Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages

Authors
Lai, XH Arencibia, I Johansson, A Wai, SN Oscarsson, J Kalfas, S Sundqvist, KG Mizunoe, Y Sjostedt, A Uhlin, BE
Citation
Xh. Lai et al., Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macrophages, INFEC IMMUN, 68(7), 2000, pp. 4363-4367
Citations number
30
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
7
Year of publication
2000
Pages
4363 - 4367
Database
ISI
SICI code
0019-9567(200007)68:7<4363:CAAEOT>2.0.ZU;2-S
Abstract
Cytolysin A (ClyA) is a newly discovered cytolytic protein of Escherichia c oli K-12 that mediates a hemolytic phenotype. We show here that highly puri fied ClyA and ClyA-expressing E. coli were cytotoxic and apoptogenic to fre sh as well as cultured human and murine monocytes/macrophages.