Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase

Authors
Banerjee, R Anguita, J Fikrig, E
Citation
R. Banerjee et al., Granulocytic ehrlichiosis in mice deficient in phagocyte oxidase or inducible nitric oxide synthase, INFEC IMMUN, 68(7), 2000, pp. 4361-4362
Citations number
24
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
7
Year of publication
2000
Pages
4361 - 4362
Database
ISI
SICI code
0019-9567(200007)68:7<4361:GEIMDI>2.0.ZU;2-Q
Abstract
Mice deficient in phox (gp91(phox-/-)) or NOS2 (NOS2(-/-)) were infected wi th the agent of human granulocytic ehrlichiosis (HGE) to evaluate the impor tance of these pathways in the eradication of HGE bacteria, NOS2(-/-) mice had delayed clearance of the HGE agent in comparison to control or gp91(pho x-/-) mice, suggesting that reactive nitrogen intermediates play a role in the early control of HGE.