The selection pressure for antibacterial resistance in the community might
not be as high as in hospitals. However, it is generally accepted that it i
s in the primary healthcare sector that one can achieve the greatest decrea
se in the total use of antimicrobials. There are significant differences in
the overall use of antimicrobials among European countries. On average, 80
% to 90% of the total antibiotic use in each country takes place in the pri
mary healthcare sector. Surveillance of the use of antimicrobials is the co
re for planning interventions and monitoring their effect. These interventi
ons may be implemented for either political, economic, or professional reas
ons. Often, but not always, political interventions are governmental, and p
rofessional interventions are recommendations from professional association
s. Examples of interventions at different levels in the Danish healthcare s
ystem, from the general practitioner to legislation by the government, will
be presented together with their effect on the use of antimicrobials (Infe
ct Control Hosp Epidemiol 2000;21:387;389).