In tills paper we analyze the possibility of estabishing a Theorem of Impri
mitivity in the case of nonlocally compact Polish groups. We Drove that sys
tems of imprimitivity for a Polish group G based on a locally compact homog
eneous G-space M = G/H equipped with a quasi-invariant probability measure
mu, are in one-to-one correspondence with elements of the space H-1(G, F-mu
(M, U(K))) of the first cohomology of the group G of equivalence classes of
continuous cocycles. As a corollary, we have the complete Imprimitivity Th
eorem H-1(G, F-mu(M, U(K))) similar to Hom(H, U(K)) in the case of discrete
countable homogeneous G-spaces equipped with a quasi-invariant measure. Fi
nally, we outline the possibility of estabishing the complete Imprimitivity
Theorem for particular classes of Polish groups. These examples cover the
case of (separable) Frechet spaces, for which it is shown that the complete
Imprimitivity Theorem holds as well.