Upper gastrointestinal tract complications due to non-steroidal anti-inflam
matory drugs are well recognised. However, adverse effects on large intesti
nal mucosa are less common and less well recognised, even though they carry
a significant morbidity and mortality. Here we report a case of colonic pe
rforation in a healthy woman without any underlying colonic pathology assoc
iated with ingestion of slow release diclofenac sodium.