Ten years of serological surveillance in England and Wales: methods, results, implications and action

Background The first age-stratified serological survey of antibody to measl es, mumps and rubella in the UK was conducted in 1986/87 prior to the intro duction of MMR vaccine into the immunization programme. Serum collection an d testing have continued annually, allowing trends over time to be monitore d. These sera have also been available for ad hoc surveys of other infectio ns. Methods Residual sera are collected in participating laboratories and sent to a central store where they are irrevocably unlinked from identifying dat a. A unique identity number is assigned to each serum and details of age an d sex are collated on a database. The sera are accessed for testing as requ ired. Results The results of recurring and other surveys performed over the last ten years are presented. These demonstrate that opportunistic serum samples are an ideal resource for serological surveillance programmes. Conclusions The serological surveillance programme has provided past exposu re profiles for many infections. These data have resulted in a number of na tional policy changes and have been instrumental in shaping the UK vaccinat ion programme.