Extraskeletal myxoid chondrosarcoma with rhabdoid features, with special reference to its aggressive behavior

Citation
Y. Oshiro et al., Extraskeletal myxoid chondrosarcoma with rhabdoid features, with special reference to its aggressive behavior, INT J SUR P, 8(2), 2000, pp. 145-152
Citations number
30
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology
Journal title
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
ISSN journal
10668969 → ACNP
Volume
8
Issue
2
Year of publication
2000
Pages
145 - 152
Database
ISI
SICI code
1066-8969(200004)8:2<145:EMCWRF>2.0.ZU;2-7
Abstract
The presence of rhabdoid cells has been reported in various types of malign ant neoplasms. Thirty-six cases of extraskeletal myxoid chondrosarcoma (EMC ) were reviewed, and three of them revealed rhabdoid features. These cases contained cells having prominent eosinophilic globular cytoplasm, but were otherwise typical of EMC. Immunohistochemically, cytokeratin (CAM 5.2) was positive in three of 20 cases (15%), including two of the three with rhabdo id features. The rhabdoid cells were also immunostained with vimentin. The 5-year survival rate in the 26 cases with follow-up information was 73%, an d the 10-year survival rate was 63%. The cases with rhabdoid features had a significantly poorer prognosis (p=0.0271). This study suggests that presen ce of rhabdoid features is a predictor of aggressive behavior in EMC, as it was shown to be in other mesenchymal neoplasms.