Study on the hydrolysis of 2-chlorobenzamide

It is reported that 2-chlorobenzamide, one of the chief degradation product s of CCU (1-(2-chlorobenzoyl)-3-(4-chlorophenyl) urea), a new insect growth regulator, is a potential carcinogen, but few studies about its environmen tal stability have been found. This paper is concerned with the hydrolysis of 8-chlorobenzamide as part of the environmental study of CCU. The results showed that 2-chlorobenzamide is relatively stable in solutions of pH = 6 and 8, for which the rate constants are 0.00286 h(-1) (R = 99.13%, SD = 0.0 095) and 0.00109 h(-1) (R = 96.70%, SD = 0.0072), respectively. Hydrolysis was more rapid in acidic (pH = 5), alkaline (pH = 10), and neutral (pH = 7) environments, with hydrolytic rate constants of 0.00417 h(-1) (R = 95.76%, SD = 9.0390), 0.00411h(-1) (R = 99.89%, SD = 0.0162) and 0.00408h(-1) (R = 98.29%, SD = 0.0237), respectively. The change of the rate of hydrolysis w ith pH showed two minima at 25 degrees C. Temperature has some impact on th e hydrolysis, showing at higher temperature the larger rate of reaction.