Dynamical complexity and temporal plasticity in pancreatic beta-cells

Authors
Bertram, R Sherman, A
Citation
R. Bertram et A. Sherman, Dynamical complexity and temporal plasticity in pancreatic beta-cells, J BIOSCI, 25(2), 2000, pp. 197-209
Citations number
59
Categorie Soggetti
Biology,"Medical Research General Topics
Journal title
JOURNAL OF BIOSCIENCES
ISSN journal
02505991 → ACNP
Volume
25
Issue
2
Year of publication
2000
Pages
197 - 209
Database
ISI
SICI code
0250-5991(200006)25:2<197:DCATPI>2.0.ZU;2-5
Abstract
We discuss some of the biological and mathematical issues involved in under standing and modelling the bursting electrical activity in pancreatic beta- cells. These issues include single-cell versus islet behaviour, parameter h eterogeneity, channel noise, the effects of hormones, neurotransmitters, an d ions, and multiple slow biophysical processes. Some of the key experiment al and modelling studies are described, and some of the major open question s are discussed.