Lack of reactivation of cytomegalovirus retinitis in an AIDS patient, during and after stopping long-term cidofovir treatment: Case report

The case of an AIDS patient with cytomegalovirus (CMV) retinitis who was tr eated with cidofovir for 17 consecutive months, without any adverse effect, is presented. In the context of antiretroviral therapy, cidofovir therapeu tic regimen was 5 mg/kg of body weight for 2 weeks and 5 mg/kg thereafter e very other week. Probenecid, hydration and monitoring for proteinuria were also used to prevent nephrotoxicity. The patient stopped maintenance therap y for CMV retinitis after the permanent rise of CD4+ cells above 100 c/mm(3 ). For more than 10 months after drug withdrawal the patient remains free o f retinitis.