A. Longhi et al., Brain tumors as second malignant neoplasms in patients with osteosarcoma treated with adjuvant and neoadjuvant chemotherapy: Report of 2 cases, J CHEMOTHER, 12(3), 2000, pp. 261-262
A malignant, primary brain tumor developed as Second Malignant Neoplasm (SM
N) in 2/490 long-term-survivor osteosarcoma patients treated at our Institu
te over a 20-yr period, They developed the brain tumor (one astrocytoma and
one glioblastoma) 3 and 5 yr after treatment, (chemotherapy and surgery),
for localized osteosarcoma of the extremity.