gThe putative hazardous nature of chloroform and xylene implies that safer
substitutes should be considered. Standard cylindrical gutta-percha samples
were immersed in Hemo-De, a xylene substitute, for 60 s at 37 degrees C. W
eight loss of a sample, after drying, was used as a measure of its solubili
ty, Master and accessory cone gutta-percha of three brands were compared, T
he highest solubility of all kinds of gutta-percha was in chloroform, which
served as a positive control. The average solubility of all samples in xyl
ene and Hemo-De was 61% and 52% of that in chloroform, respectively. DMS gu
tta-percha was more soluble than of Hygienic and DeTrey, Master cone gutta-
percha of all brands was more soluble than that of their accessory cones. T
hese results indicate that (a) large differences exist in the solubility of
gutta-percha and (b) Hemo-De dissolved gutta-percha in a range similar to
that of xylene and may be considered as a potential substitute for this org
anic solvent.