In the last years, several single-bottle dental adhesives have been develop
ed. They are supposed to chemically adhere to dentin, and a liner to protec
t pulp is not thought to be necessary. In the case of direct pulp capping,
hemorrhage control is an important step in success, but little is known abo
ut the effect of these new bonding agents on pulpal bleeding. The aim of th
is study was to evaluate the effect of a new one-step single-bottle adhesiv
e on the smooth muscle contraction of rat uterine muscle and carotid arteri
es. Efficacy of the bonding agent was compared with that of epinephrine (co
ntrol), and the contraction forces induced were recorded using a force disp
lacement transducer. Statistical analysis of data revealed that the bonding
material produced epinephrine-like concentration-dependent contractions of
the smooth muscle, suggesting that onestep bonding agents may act as candi
dates for hemorrhage control without the use of an additional agent in dire
ct pulp capping procedures.