Synthesis of [25, 26, 26, 26, 27, 27, 27-d(7)]-cholesterol

Authors
Chu, GH Li, PK
Citation
Gh. Chu et Pk. Li, Synthesis of [25, 26, 26, 26, 27, 27, 27-d(7)]-cholesterol, J LABEL C R, 43(8), 2000, pp. 773-779
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
43
Issue
8
Year of publication
2000
Pages
773 - 779
Database
ISI
SICI code
0362-4803(200007)43:8<773:SO[222>2.0.ZU;2-F
Abstract
An efficient synthesis of [25, 26, 26, 26, 27, 27, 27-d(7)]-cholesterol 1, a useful tool for the measurement of cholesterol absorption, is described. Commercially available stigmasterol is converted into the known aldehyde 2 which was then transformed to the d(7)-cholesterol 1 through a reaction seq uence of 8 steps in an overall yield of 22.5%.