Prospects in computational molecular medicine: a millennial mega-project on peptide folding

During the second half of the 20th century, Molecular Computations have rea ched to a level that can revolutionize chemistry. The next target will be s tructural biology, which will be followed soon by Molecular Medicine. The p resent paper outlines where we are at, in this field, at the end of the 20t h century, and in what direction the development may take in the new millen nium. In view of the gigantic nature of the problem, it is suggested that a suitably designed cooperative Millennial Mega-project might accelerate our schedule. (C) 2000 Elsevier Science B.V. All rights reserved.