Clinico-immunogenetic characteristics of multiple sclerosis with optic neuritis in children

The frequency of multiple sclerosis (MS) with clinical onset before 16 year s of age in different regions of Russia fluctuates from 2 to 10% of all MS patients. One of the most frequent signs of MS manifestation and/or exacerb ation at this age is optic neuritis (ON). Forty-seven children with MS were observed in Moscow. Diagnosis of MS in every case was clinically definite and proved by serial MRI. Clinico-tomographic dissociation was noticed: num erous large lesions, typical for MS on T2 images were often seen in childre n with mild or moderate residual neurological symptoms. All patients had re lapsing/remitting MS course, mean EDSS was 2.24 +/- 0.26. Thirty-eight chil dren (80%) had ON at least once, ten (21.3%) -twice or more times. In sever al cases ON had subclinical course or might be missed and the damage of the optic nerve with partial atrophy was found only after complex ophthalmolog ical investigation including visual evoked potentials. Thus, the clinical c ourse of MS and ON have some peculiarities in children and may be genetical ly based. Analyses of allelic polymorphisms of HLA-DR and TNF loci on chrom osome 6 was performed. Data from children with MS were compared with data f rom their parents, healthy controls and other MS patients from the same eth nic group. Children with MS had increased frequency of DR2(15) and TNF-all, but not TNF-a9 as adult MS patients from the same ethnic group. The presen ce of TNF-a7, rare in adult patients, could be proposed as a marker of earl y MS onset.