This study is among the first to estimate the overall economic burden of rh
eumatoid arthritis (RA) from an employer perspective. The annual, per capit
a cost of RA was determined for beneficiaries of a major employer by analyz
ing medical, pharmaceutical, and disability claims data. The incremental co
sts related to RA were determined by matching RA patients to a case-control
group of individuals with no recorded RA treatment. The utilization of hea
lth care services as well as the rate of disability among RA patients was s
ubstantially higher than among the controls. For example, annual per capita
employer expenditures for RA employees with disability were almost 3 times
those of their controls ($17,822 vs $6131, respectively). Treatment to add
ress not only the severity but also the progression of RA may substantially
reduce overall employer expenditures for this disease.