Synthesis of macrocyclic cage compounds by diamine-dihalide one-step coupling reaction

Macropolycyclic cage compounds were synthesized by a direct reaction betwee n diamines and bis(bromomethyl) compounds. The procedure for constructing t he polycyclic cage structure is simple and straightforward. The macropolycy clic compounds obtainable from this cyclization procedure are three-dimensi onal cage compounds, and any other isomers were not obtained except for two examples. Benzene, pyridine, and aliphatic units could be introduced into the cage structure. The macrocycles that have strong cation affinity were o btained as their potassium complexes.