Anthraquinone-oligodeoxynucleotide conjugates as inhibitors of gene transcription

Citation
V. Gibson et al., Anthraquinone-oligodeoxynucleotide conjugates as inhibitors of gene transcription, J PHARM PHA, 52(6), 2000, pp. 599-602
Citations number
12
Categorie Soggetti
Pharmacology & Toxicology
Journal title
JOURNAL OF PHARMACY AND PHARMACOLOGY
ISSN journal
00223573 → ACNP
Volume
52
Issue
6
Year of publication
2000
Pages
599 - 602
Database
ISI
SICI code
0022-3573(200006)52:6<599:ACAIOG>2.0.ZU;2-C
Abstract
Several anthraquinone-oligodeoxynucleotide conjugates have been synthesized and their inhibition of transcription of the bla gene in E, coli has been determined. All conjugates at 10 mu M inhibited transcription and three conjugates inhi bited mRNA production by 40 to 50% for periods of up to 60 min.