Quantitative 3-dimensional contrast echocardiographic determination of myocardial mass at risk and residual infarct mass after reperfusion: Experimental canine studies with intravenous contrast agent NC100100

Two-dimensional contrast echocardiography has been shown to enable the eval uation of myocardial perfusion abnormalities. However, its ability to quant ify a regional myocardial mass is limited. The goal of this study was to ex amine the quantitative value of 3-dimensional echocardiography (3DE) in the estimation of myocardial mass at risk salvaged mass, and residual Infarct mass after intravenous injection of contrast. We created acute coronary occ lusion, followed by reperfusion in 10 dogs. Three-dimensional echocardiogra phic data were acquired at the end of each stage, and the perfusion defect mass and dysfunctional mass were measured. The true mass at risk and infarc t mass were determined by anatomic methods. The anatomic mass at risk (x) ( 27.1 +/- 14.6 g or 23.8% +/- 9.7% of the left ventricle [%LV]) correlated w ell with the 3DE-determined perfusion defect mass (y) during coronary occlu sion (y = 0.5x + 8.9; r = 0.90; P <.001; mean difference -4.8 +/- 8.1 g; or y = 0.7x + 6.5; r = 0.83, P < .01; mean difference -0.1 +/- 5.4 %LV). Good correlation was also found between the anatomic infarct mass (x) (93.3 +/- 8.1 g or 9.1 +/- 8.8 %LV) and the 3DE perfusion defect mass after reperfus ion (Y) (Y = 1.2x + 1.2; r - 0.93; P < .001; mean difference 2.3 +/- 4.0 g; or y = 1.3x, r = 0.98, p < .0001; mean difference 2.7 +/- 3.7 %LV). The sa lvaged mass was 13.6 +/- 11.0 %LV from anatomic methods and 14.2 +/- 13.0 % LV by 3DE. To conclude, with the use of intravenous contrast 3DE could quan tify the actual mass at risk during acute ischemia, and in the setting of r eperfusion, the residual Infarct mass and salvaged mass.