RESEARCH STRATEGY FOR THE HPLC FT-IR ANALYSIS OF DRUG METABOLITES/

Authors
PIVONKA DE KIRKLAND KM
Citation
De. Pivonka et Km. Kirkland, RESEARCH STRATEGY FOR THE HPLC FT-IR ANALYSIS OF DRUG METABOLITES/, Applied spectroscopy, 51(6), 1997, pp. 866-873
Citations number
14
Categorie Soggetti
Instument & Instrumentation",Spectroscopy
Journal title
Applied spectroscopy → ACNP
ISSN journal
00037028
Volume
51
Issue
6
Year of publication
1997
Pages
866 - 873
Database
ISI
SICI code
0003-7028(1997)51:6<866:RSFTHF>2.0.ZU;2-4
Abstract
A strategy for the infrared spectroscopic analysis of drug metabolites in high-pressure liquid chromatography (HPLC) effluent is presented w ith a primary focus on delivery of metabolite structure as opposed to development of dedicated or automated instrumentation. This paper stre sses the complementary nature of on-line (solution phase) and off-line (condensed phase) HPLC Fourier transform infrared (FT-IR) implementat ions for structural elucidation of drug metabolites.