Stability and sterility of recombinant tissue plasminogen activator at-30 degrees C

Authors
Wiernikowski, J Crowther, M Clase, CM Ingram, A Andrew, M Chan, AKC
Citation
J. Wiernikowski et al., Stability and sterility of recombinant tissue plasminogen activator at-30 degrees C, LANCET, 355(9222), 2000, pp. 2221-2222
Citations number
4
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
355
Issue
9222
Year of publication
2000
Pages
2221 - 2222
Database
ISI
SICI code
0140-6736(20000624)355:9222<2221:SASORT>2.0.ZU;2-J
Abstract
We assessed whether frozen recombinant tissue plasminogen activator (rt-PA) remains stable and sterile for up to 22 weeks at -30 degrees C. Our findin gs confirm that rt-PA is a cost-effective alternative to urokinase for rest oring patency to occluded central venous catheters.