Interactions between phenylephrine, clonidine and xylazine in rat and rabbit aortas

Authors
Atalik, KE Sahin, AS Dogan, N
Citation
Ke. Atalik et al., Interactions between phenylephrine, clonidine and xylazine in rat and rabbit aortas, METH FIND E, 22(3), 2000, pp. 145-147
Citations number
16
Categorie Soggetti
Pharmacology & Toxicology
Journal title
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
ISSN journal
03790355 → ACNP
Volume
22
Issue
3
Year of publication
2000
Pages
145 - 147
Database
ISI
SICI code
0379-0355(200004)22:3<145:IBPCAX>2.0.ZU;2-V
Abstract
The interaction of the alpha(2)-adrenoceptor agonists clonidine and xylazin e with the alpha(1)-aduenoceptors in the mt and rabbit aortas was investiga ted In preparations preconstructed with phenylephrine (10(-6) M), cumulativ e addition of clonidine and xylazine induced concentration-related vasodila tation in the presence of the alpha(2)-adrenoceptor antagonist yohimbine an d the P-blocker propranolol. Neither clonidine nor xylazine treatment inhib ited 5-HT- and KCI-induced vasoconstriction. It is concluded that alpha(1)- agonists have affinity for alpha(1)-adrenoceptors in rat and rabbit aortas. () 2000 Prous Science. All rights reserved.