Progress toward the development of a vaccine to prevent Moraxella (Branhamella) catarrhalis infections

Moraxella catarrhalis is a major cause of otitis media and respiratory dise ase. Vaccine development is at the antigen identification stage. This revie w examines the more promising antigens, including the 200K protein, the hem agglutinins, the lactoferrin-binding proteins, the UspA proteins, the CopB protein, the transferrin-binding proteins, the CD protein, the E protein an d lipooligosaccharide conjugates. Clinical testing of some of these antigen s should begin soon. (C) 2000 Editions scientifiques et medicales Elsevier SAS.