TaqIB allele polymorphism of the dopamine receptor D2 gene in patients with endogenous psychoses

The genotype at the TaqIB locus of the dopamine receptor D2 (DRD2) gene was established by PCR in 113 healthy donors and 340 patients with endogenous psychoses. The allele and genotype frequencies in patients with affective p sychoses significantly differed from those in controls and in patients with schizophrenia. The proportion of B2/B2 homozygotes decreased with increasi ng contribution of the affective component to the clinical manifestation of schizo-affective and affective disorders. The TaqIB polymorphism was assum ed to play a role in mood aberrations in patients with mental disorders.