Molecular design based on polyribonucleotides fixed in the structure of liquid-crystalline dispersion and cross-linked via polymeric chelate bridges

A method of molecular design based on cross-linking of polyribonucleotide m olecules with poly meric chelate bridges (anthracyclineCu(2+)-...-Cu2+-anth racycline) was developed. The formation of polymeric chelate cross-bridges between neighboring polyribonucleotide molecules in the particles of liquid -crystalline dispersions was shown to require the formation of external com plex (anthracydine-polyribonucleotide). The properties (shape, size, optica l activity, etc,) of molecular constructions composed of different polyribo nucleotides were studied and compared. Molecular constructions on the basis of polyribonucleotides could be used as sensing elements with adjustable p roperties in biosensor technology, nanobiotechnology, and molecular pharmac ology.