Histology of vessels of the forearm in 227 hemodialysis patients showed med
ial fibrosis more often than medial calcinosis or intimal sclerosis. In rel
ation to primary disease of renal failure, glomerulonephritis occurred more
often than diabetes mellitus or interstitial nephritis. In patients with t
he histological state of medial calcinosis, diabetes was the most often pri
mary disease of renal failure. Calcium-phosphorus product was significantly
higher in patients with medial calcinosis than in patients with medial fib
rosis. A significantly higher calcium-phosphorus product was found in the s
tate of medial calcinosis in patients with gastrointestinal/liver diseases
and "abuse patients" than in patients getting Al(OH)(3) therapy. Continuous
calcification of vessels in patients with medial calcinosis in histology o
f arterial wall appeared in X-rays of pelvis earlier than in X-rays of the
hands. The frequency of medial calcinosis increases in older patients with
diabetes and hypertension. Both secondary HPT and osteopenia can lead to me
dial calcinosis. An excessive suppression of secondary HPT can promote deve
lopment of medial calcinosis - in individual case even Al3+ can be found in
arterial wall. We must distinguish calcifying continuous uremic arteriolop
athy and non-continuous arteriosclerotic formation of plaques. A correlatio
n is found between dimension of calcification of aorta and the level of cal
cium-phosphorus product, diabetics tend to marked calcifications. The death
rate of hemodialysis patients increases with ascending levels of calcium-p
hosphorus product. Calcium and PTH (parathyroid hormone) is not so importan
t in the development of arteriosclerosis and calcinosis of vessels as calci
um-phosphorus product.