Synthesis and evaluation of a new series of 17 alpha-[I-123]iodovinyl estradiols

Authors
Kabalka, GW Shoup, TM Daniel, GB Goodman, MM
Citation
Gw. Kabalka et al., Synthesis and evaluation of a new series of 17 alpha-[I-123]iodovinyl estradiols, NUCL MED BI, 27(3), 2000, pp. 279-287
Citations number
30
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
09698051 → ACNP
Volume
27
Issue
3
Year of publication
2000
Pages
279 - 287
Database
ISI
SICI code
0969-8051(200004)27:3<279:SAEOAN>2.0.ZU;2-D
Abstract
A series of 17 alpha-substituted estradiols was synthesized in which the st ereochemical characteristics of carbons 20 and 21 were modified. It was fou nd that the (Z)-isomer demonstrated more favorable receptor binding affinit y than the corresponding (E)-isomer. NUCL MED BIOL 27;3:279-287, 2000. (C) 2000 Elsevier Science Inc. All rights reserved.