N. Perek et al., Involvement of the glutathione S-conjugate compounds and the MRP protein in Tc-99m-tetrofosmin and Tc-99m-sestamibi uptake in glioma cell lines, NUCL MED BI, 27(3), 2000, pp. 299-307
The objective of this study was to compare the accumulation of Tc-99m-tetro
fosmin and Tc-99m sestamibi in four grade IV glioma cell lines and to corre
late their accumulation with the multidrug resistance of the cells. Tc-99m-
tetrofosmin in all glioma cell lines showed slightly higher uptake and more
efficient release beyond 150 min than Tc-99m-sestamibi and the retention o
f both tracers in the cells was to a certain extend inversely proportional
to their degree of multidrug resistance. The results obtained showed that t
he efflux of both tracers was carried out only in part through the MRP/GS-X
pump system, Tc-99m-tetrofosmin showed good potential as a marker of recur
rent malignant glioma and in vivo studies are currently underway to confirm
these observations. NUCL MED BIOL 27;3:299-307, 2000. (C) 2000 Elsevier Sc
ience Inc. All rights reserved.