Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligandcarazolol in the Ames test

Authors
Doze, P Elsinga, PH de Vries, EFJ Van Waarde, A Vaalburg, W
Citation
P. Doze et al., Mutagenic activity of a fluorinated analog of the beta-adrenoceptor ligandcarazolol in the Ames test, NUCL MED BI, 27(3), 2000, pp. 315-319
Citations number
25
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
NUCLEAR MEDICINE AND BIOLOGY
ISSN journal
09698051 → ACNP
Volume
27
Issue
3
Year of publication
2000
Pages
315 - 319
Database
ISI
SICI code
0969-8051(200004)27:3<315:MAOAFA>2.0.ZU;2-W
Abstract
S-1'[F-18]-Fluorocarazolol (FCAR) is a fluorinated analog of the nonmutagen ic beta-blocker carazolol (CAR). Tn former studies FCAR proved to be suitab le for quantification of beta-adrenoceptors in vivo with positron emission tomography (PET). We report here that FCAR displays no acute toxicity in ei ther rats or mice. However, FCAR induces a strong dose-related increase in the number of revertants in the Ames test. We conclude that FCAR yields mut agenic activity as measured by the Ames test. NUCL MED BIOL 27;3:315-319, 2 000. (C) 2000 Elsevier Science Inc. All rights reserved.