POLYMORPHISM IN THE HUMAN E-SELECTIN GENE DETECTED BY PCR-SSCP

By using the non-isotopic single-strand conformation polymorphism (SSC P) technique to analyse products of the polymerase chain reaction (PCR ), we detected a 561-adenine to cytosine substitution resulting in an amino acid exchange from serine to arginine at position 128 of the E-s electin gene. If this amino acid substitution has an effect on the adh esion of blood cells to the endothelium, the polymorphism could be of interest with respect to association studies in a number of pathologic al conditions, such as cardiovascular diseases.