Synthesis of 6,7-dialkoxy-2-arylmethylidene-2,3-dihydrobenzo[4,5]imidazo[2,1-b][1,3]thiazol-3-ones exhibiting anti-inflammatory activity

New 6,7-dialkoxy-2-arylmethylidene-2,3-dihydrobenzo[4,5]imidazo[2,1-b][1,3] thiazol-3-ones (3a-h, 4b, c, e, g) were synthesized from 2-(5,6-dialkoxy-1H -benzo[d]imidazol-2-ylsulfanyl)acetic acids (1, 2) and corresponding aromat ic aldehydes in acetic anhydride. The compounds 3e, f and 4b, g were also s ynthesized from corresponding aromatic aldehydes and 6,7-dialkoxy-2,3-dihyd robenzo[4,5]imidazo[2,1-b][1,3]thiazol-3-ones (5, 6) obtained by the cycliz ation of the acids 1 and 2 in acetic anhydride. The synthesized compounds 3 a-h and 4b, c, e, g exhibit anti-inflammatory activity.