The treatment of delayed polyneuropathy induced by diisopropylfluorophosphate in hens

This study was undertaken to examine the influence of atropine, oximes and benzodiazepine on organophosphate-induced delayed polyneuropathy (OPIDP) in hens, which were poisoned with diisopropylfluorophosphate (DFP). The birds were treated with a standard neuropathic dose of DFP (1.1 mg/kg, sc), whic h produced typical signs of OPIDP. The development of OPIDP was observed wi thin the followings 22 days. All drugs were given subcutaneously (sc). intr amuscularly (im) or intraperitoneally (ip), 20 min before the poison. The r esults obtained have shown that atropine (20 mg/kg, ip) only in combination with oxime TMB-4 (15 mg/kg, im) produced significant improvement of OPIDP symptoms in comparison with positive control. Clinical signs and symptoms o f OPIDP in the group which was treated with atropine (20 mg/kg, ip), TMB-4 (15 mg/kg, im) and midazolam (2.5 mg/kg, im) were more improved than that i n the presence of a combination of atropine and TMB-4. The results of these experiments have shown that it is possible to pi-event the development of DFP-induced OPIDP in hens by treatment with atropine and TMB-4 or atropine, TMB-4 and midazolam when given before DFP.