Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa

Authors
Neto, CC Vaisberg, AJ Zhou, BN Kingston, DGI Hammond, GB
Citation
Cc. Neto et al., Cytotoxic triterpene acids from the Peruvian medicinal plant Polylepis racemosa, PLANTA MED, 66(5), 2000, pp. 483-484
Citations number
17
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
00320943 → ACNP
Volume
66
Issue
5
Year of publication
2000
Pages
483 - 484
Database
ISI
SICI code
0032-0943(200006)66:5<483:CTAFTP>2.0.ZU;2-R
Abstract
Cytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acet ylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI(50) values of 6.9 and 8.3 mu g/mL respectively.